Protein Family Models

This family represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). [1]. 9573603. Cupins: a new superfamily of functionally diverse proteins that. include germins and plant storage proteins.. Dunwell JM;. Biotechnol Genet Eng Rev 1998;15:1-32. (from Pfam)

Date:

2024-08-14

All of the members of this Pfam entry belong to family 2 of the mannose-6-phosphate isomerases. The type II phosphomannose isomerases are bifunctional enzymes. This Pfam entry covers the isomerase domain. The guanosine diphospho-D-mannose pyrophosphorylase domain is in another Pfam entry, see Pfam:PF00483. [1]. 9507048. Domain organisation in phosphomannose isomerases (types I and. II).. Jensen SO, Reeves PR;. Biochim Biophys Acta 1998;1382:5-7. (from Pfam)

Date:

2024-08-14

This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars. [1]. 9507048. Domain organisation in phosphomannose isomerases (types I and. II).. Jensen SO, Reeves PR;. Biochim Biophys Acta 1998;1382:5-7. (from Pfam)

Date:

2024-08-14

This enzyme is known to be bifunctional, as both mannose-6-phosphate isomerase (EC 5.3.1.8) (PMI) and mannose-1-phosphate guanylyltransferase (EC 2.7.7.22) in Pseudomonas aeruginosa, Xanthomonas campestris, and Gluconacetobacter xylinus. The literature on the enzyme from E. coli attributes mannose-6-phosphate isomerase activity to an adjacent gene, but the present sequence has not been shown to lack the activity. The PMI domain is C-terminal.

Date:

2024-05-14