Protein Family Models for Protein (Select 1944572042) - Protein Family Models

Select item 4325971.

Deacetylase EF_0837-like composite domain

Date:: 2024-08-14

Family Accession:: NF047233.1
Method:: HMM

Select item 4174602.

amidohydrolase family protein

Date:: 2024-08-14

Family Accession:: NF019581.5
Method:: HMM

Select item 4123043.

amidohydrolase family protein

This family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5]. [1]. 9144792. An evolutionary treasure: unification of a broad set of. amidohydrolases related to urease.. Holm L, Sander C;. Proteins 1997;28:72-82.. [2]. 8550522. Role of adenine deaminase in purine salvage and nitrogen. metabolism and characterization of the ade gene in Bacillus. subtilis.. Nygaard P, Duckert P, Saxild HH;. J Bacteriol 1996;178:846-853.. [3]. 7754395. The crystal structure of urease from Klebsiella aerogenes.. Jabri E, Carr MB, Hausinger RP, Karplus PA;. Science 1995;268:998-1004.. [4]. 9878395. Novel organization and sequences of five genes encoding all six. enzymes for de novo pyrimidine biosynthesis in Trypanosoma. cruzi.. Gao G, Nara T, Nakajima-Shimada J, Aoki T;. J Mol Biol 1999;285:149-161.. [5]. 8590465. As in Saccharomyces cerevisiae, aspartate transcarbamoylase is. assembled on a multifunctional protein including a. dihydroorotase-like cryptic domain in Schizosaccharomyces pombe.. Lollier M, Jaquet L, Nedeva T, Lacroute F, Potier S, Souciet JL;. Curr Genet 199. TRUNCATED at 1650 bytes (from Pfam)

GO Terms:

Molecular Function:: hydrolase activity (GO:0016787)

Date:: 2024-08-14

Family Accession:: NF014081.5
Method:: HMM

Select item 3947894.

new record, indexing in progress

Family Accession:

Select item 3907385.

new record, indexing in progress

Family Accession:

Select item 3568216.

new record, indexing in progress

Family Accession:

Select item 3472697.

new record, indexing in progress

Family Accession:

Select item 1682108.

amidohydrolase/deacetylase family metallohydrolase

GO Terms:

Molecular Function:: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810)

Molecular Function:: deacetylase activity (GO:0019213)

Date:: 2021-10-04

Family Accession:: NF006689.0
Method:: HMM

Select item 1474379.

amidohydrolase/deacetylase family metallohydrolase

Members of this family of relatively uncommon proteins are found in both Gram-positive (e.g. Enterococcus faecalis) and Gram-negative (e.g. Aeromonas hydrophila) bacteria, as part of a cluster of conserved proteins. These proteins resemble aminohydrolases (see PF01979), including dihydroorotases. The function is unknown.

Date:: 2024-08-07

Family Accession:: TIGR03583.1
Method:: HMM

Select item 10828010.

amidohydrolase/deacetylase family metallohydrolase

amidohydrolase/deacetylase family metallohydrolase similar to Bradyrhizobium diazoefficiens dihydroorotase which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines

Date:: 2019-06-17

Family Accession:: 10793177
Method:: Sparcle

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