Protein Family Models

This poorly understood protein family consists of small and highly divergent proteins, about 65 amino long, making detection difficult, but is widely distributed in Gram-negative bacteria. PA3496 from Pseudomonas aeruginosa was shown to be upregulated somewhat in the presence of inulin or inulin-derived fructooligosaccharide. Moraxella catarrhalis strains in which MCR_0424 is knocked out by mutation have a severe defect in resistance to complement present in serum. The latter result suggests a role as a cell envelope integrity protein. This family appears related to Pfam family PF12065 (DUF3545), and probably should be considered as a related model from a broader clan.

Date:

2024-07-02