Protein Family Models

Date:

2024-08-14

This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH [1]. [1]. 1657980. Expression of a sodium proton antiporter (NhaA) in Escherichia. coli is induced by Na+ and Li+ ions.. Karpel R, Alon T, Glaser G, Schuldiner S, Padan E;. J Biol Chem 1991;266:21753-21759. (from Pfam)

Date:

2024-08-14

This family contains a diverse set of proteins with a thioredoxin-like structure Pfam:PF00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways [2,3,4]. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs (e.g. Swiss:P24473), whose similarity to HCCA isomerases was not previously recognised. The sequence Swiss:O07298 has been annotated as a dioxygenase but is almost certainly an HCCA isomerase enzyme. Similarly, the sequence Swiss:Q9ZI67 has been annotated as a dehydrogenase, but is most probably also an HCCA isomerase enzyme. In addition, the Rhizobium leguminosarum Swiss:Q52782 protein has been annotated as a putative glycerol-3-phosphate transfer protein, but is also most likely to be an HCCA isomerase enzyme (see [5]). [1]. 9149147. Structure of TcpG, the DsbA protein folding catalyst from Vibrio. cholerae.. Hu SH, Peek JA, Rattigan E, Taylor RK, Martin JL;. J Mol Biol 1997;268:137-146.. [2]. 8226631. Metabolism of dibenzothiophene and naphthalene in Pseudomonas. strains: complete DNA sequence of an upper naphthalene catabolic. pathway.. Denome SA, Stanley DC, Olson ES, Young KD;. J Bacteriol 1993;175:6890-6901.. [3]. 8002605. Organization and evolution of naphthalene catabolic pathways:. sequence of the DNA encoding 2-hydroxychromene-2-carboxylate. isomerase and trans-o-hydroxybenzylidenepyruvate. hydratase-aldolase from the NAH7 plasmid.. Eaton RW;. J Bacteriol 1994;176:7757-7762.. [4]. 9882667. The phn genes of Burkholderia sp. strain RP007 const. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

Na_H_antiport_1 and DsbG domain-containing protein

Date:

2017-03-02

These proteins are members of the NhaA Na+:H+ Antiporter (NhaA) Family (TC. 2.A.33). The Escherichia coli NhaA protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent. Only the E. coli protein is functionally and structurally well characterized.

Gene:

nhaA

Date:

2024-06-04