This domain called GIY-YIG is found in the amino terminal region of excinuclease abc subunit c (uvrC), bacteriophage T4 endonucleases segA, segB, segC, segD and segE; it is also found in putative endonucleases encoded by group I introns of fungi and phage. The structure of I-TevI a GIY-YIG endonuclease, reveals a novel alpha/beta-fold with a central three-stranded antiparallel beta-sheet flanked by three helices [4]. The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site. [1]. 1631169. Identification of a family of bacteriophage T4 genes encoding. proteins similar to those present in group I introns of fungi. and phage.. Sharma M, Ellis RL, Hinton DM;. Proc Natl Acad Sci U S A 1992;89:6658-6662.. [2]. 9973609. Conserved domains in DNA repair proteins and evolution of repair. systems.. Aravind L, Walker DR, Koonin EV;. Nucleic Acids Res 1999;27:1223-1242.. [3]. 10219084. Configuration of the catalytic GIY-YIG domain of intron. endonuclease I-TevI: coincidence of computational and molecular. findings.. Kowalski JC, Belfort M, Stapleton MA, Holpert M, Dansereau JT,. Pietrokovski S, Baxter SM, Derbyshire V;. Nucleic Acids Res 1999;27:2115-2125.. [4]. 12379841. Catalytic domain structure and hypothesis for function of. GIY-YIG intron endonuclease I-TevI.. Van Roey P, Meehan L, Kowalski JC, Belfort M, Derbyshire V;. Nat Struct Biol 2002;9:806-811.. [5]. 16646971. Phylogenomic analysis of the GIY-YIG nuclease superfamily.. Dunin-Horkawicz S, Feder M, Bujnicki JM;. BMC Genomics. 2006;7:98. (from Pfam)
- Date:
- 2024-08-14