Protein Family Models

Date:

2024-08-14

This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. (from Pfam)

Date:

2024-08-14

The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. [1]. 9068629. The Salmonella typhimurium mar locus: molecular and genetic. analyses and assessment of its role in virulence.. Sulavik MC, Dazer M, Miller PF;. J Bacteriol 1997;179:1857-1866.. [2]. 11473263. The crystal structure of MarR, a regulator of multiple. antibiotic resistance, at 2.3 A resolution.. Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF;. Nat Struct Biol 2001;8:710-714. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter [2] in Thermococcus litoralis. [1]. 8594196. Genetics of a novel starch utilisation pathway present in. Klebsiella oxytoca.. Fiedler G, Pajatsch M, Bock A;. J Mol Biol 1996;256:279-291.. [2]. 12426307. TrmB, a sugar-specific transcriptional regulator of the. trehalose/maltose ABC transporter from the hyperthermophilic. archaeon Thermococcus litoralis.. Lee SJ, Engelmann A, Horlacher R, Qu Q, Vierke G, Hebbeln C,. Thomm M, Boos W;. J Biol Chem 2003;278:983-990. (from Pfam)

Date:

2024-08-14

The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. [1]. 9068629. The Salmonella typhimurium mar locus: molecular and genetic. analyses and assessment of its role in virulence.. Sulavik MC, Dazer M, Miller PF;. J Bacteriol 1997;179:1857-1866.. [2]. 11473263. The crystal structure of MarR, a regulator of multiple. antibiotic resistance, at 2.3 A resolution.. Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF;. Nat Struct Biol 2001;8:710-714. (from Pfam)

Date:

2024-08-14

Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition. [1]. 9466913. Crystal structure of the cyanobacterial metallothionein. repressor SmtB: a model for metalloregulatory proteins.. Cook WJ, Kar SR, Taylor KB, Hall LM;. J Mol Biol 1998;275:337-346. (from Pfam)

Date:

2024-08-14