Protein Family Models

SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway. Structure of SIS domain. [1]. 9739095. Involvement of the C terminus in intramolecular nitrogen. channeling in glucosamine 6-phosphate synthase: evidence from a. 1.6 A crystal structure of the isomerase domain.. Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B, Polikarpov. I;. Structure 1998;6:1047-1055.. [2]. 10203754. The SIS domain: a phosphosugar-binding domain.. Bateman A;. Trends Biochem Sci 1999;24:94-95. (from Pfam)

Date:

2024-08-14

Members of this protein family are 6-phospho 3-hexuloisomerase (PHI), or the PHI domain of a fusion protein. This enzyme is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin.

Gene:

hxlB

Date:

2024-06-21

6-phospho-3-hexuloisomerase (PHI) catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate

Date:

2019-03-18