Protein Family Models

This presumed domain is about 120 amino acids in length. It is found associated with CBS domains Pfam:PF00571, as well as the CbiA domain Pfam:PF01656. The function of this domain is unknown. It is named the DRTGG domain after some of the most conserved residues. This domain may be very distantly related to a pair of CBS domains. There are no significant sequence similarities, but its length and association with CBS domains supports this idea (Bateman A, pers. obs.). (from Pfam)

Date:

2024-08-14

This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members [1]. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus. [1]. 9478130. A novel family of predicted phosphoesterases includes Drosophila. prune protein and bacterial RecJ exonuclease.. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:17-19. (from Pfam)

Date:

2024-08-14

It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ. [1]. 9478130. A novel family of predicted phosphoesterases includes Drosophila. prune protein and bacterial RecJ exonuclease.. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:17-19. (from Pfam)

Date:

2024-08-14

CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [5]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet [4]. CBS domain pairs from AMPK bind AMP or ATP [5]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [5]. Discovery and naming of the CBS domain.. [1]. 9020585. The structure of a domain common to archaebacteria and the. homocystinuria disease protein.. Bateman A;. Trends Biochem Sci 1997;22:12-13.. 3D Structure found as a sub-domain in TIM barrel of. inosine-monophosphate dehydrogenase.. [2]. 10200156. Characteristics and crystal structure of bacterial. inosine-5'-monophosphate dehydrogenase.. Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E,. Joachimiak A, Collart FR;. Biochemistry 1999;38:4691-4700.. Discovery of CBS domain.. [3]. 9106071. CBS domains in ClC chloride channels implicated in myotonia and. nephrolithiasis (kidney stones).. Ponting CP;. J Mol Med 1997;75:160-163.. [4]. 11524006. Regulation of human cystathionine beta-synthase by. S-adenosyl-L-methionine: evidence for two catalytically active. conformations involving an autoinhibitory domain in the. C-terminal region.. Janosik M, Kery V, . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

cobalt/manganese-dependent inorganic pyrophosphatase catalyzes the hydrolysis of pyrophosphate to phosphate

Date:

2018-05-21