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SDR family oxidoreductase
This domain is found in Enoyl-(Acyl carrier protein) reductases. (from Pfam)
KR domain-containing protein
This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group [1]. [1]. 23790488. Structural and stereochemical analysis of a modular polyketide. synthase ketoreductase domain required for the generation of a. cis-alkene.. Bonnett SA, Whicher JR, Papireddy K, Florova G, Smith JL,. Reynolds KA;. Chem Biol. 2013;20:772-783. (from Pfam)
NAD-dependent epimerase/dehydratase family protein
This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions. [1]. 9174344. Structural analysis of UDP-sugar binding to UDP-galactose. 4-epimerase from Escherichia coli.. Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden. HM;. Biochemistry 1997;36:6294-6304. (from Pfam)
SDR family NAD(P)-dependent oxidoreductase
This family contains a wide variety of dehydrogenases. [1]. 9735295. The refined crystal structure of Drosophila lebanonensis alcohol. dehydrogenase at 1.9 A resolution.. Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R;. J Mol Biol 1998;282:383-399.. [2]. 10387002. Structure of tropinone reductase-II complexed with NADP+ and. pseudotropine at 1.9 A resolution: implication for. stereospecific substrate binding and catalysis.. Yamashita A, Kato H, Wakatsuki S, Tomizaki T, Nakatsu T,. Nakajima K, Hashimoto T, Yamada Y, Oda J;. Biochemistry 1999;38:7630-7637. (from Pfam)
classical SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase may catalyze isomerization, decarboxylation, epimerization, C=N bond reduction, dehydration, dehalogenation, enoyl-CoA reduction, and/or carbonyl-alcohol oxidoreduction; classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue
SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase similar to Bacillus subtilis NADPH-dependent reductase BacG, which is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin
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