Protein Family Models for Protein (Select 2119208481) - Protein Family Models

Select item 3902321.

non-canonical purine NTP pyrophosphatase

This family consists of the HAM1 protein Swiss:P47119 and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae Swiss:P47119 [1]. The HAM1 protein protects the cell from HAP, either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions [1]. [1]. 8789257. HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity. and mutagenesis in the yeast Saccharomyces cerevisiae.. Noskov VN, Staak K, Shcherbakova PV, Kozmin SG, Negishi K, Ono. BC, Hayatsu H, Pavlov YI;. Yeast 1996;12:17-29. (from Pfam)

GO Terms:

Biological Process:: nucleoside triphosphate catabolic process (GO:0009143)

Molecular Function:: nucleoside triphosphate diphosphatase activity (GO:0047429)

Date:: 2024-04-03

Family Accession:: NF013854.4
Method:: HMM

Select item 3474172.

new record, indexing in progress

Family Accession:

Select item 3177153.

new record, indexing in progress

Family Accession:

Select item 1967794.

non-canonical purine NTP pyrophosphatase

RdgB/HAM1 family pyrophosphatase that hydrolyzes non-canonical purine nucleotides to their respective monophosphates and prevents their incorporation into DNA

GO Terms:

Molecular Function:: nucleoside triphosphate diphosphatase activity (GO:0047429)

Biological Process:: purine nucleoside triphosphate catabolic process (GO:0009146)

Molecular Function:: nucleotide binding (GO:0000166)

Date:: 2023-02-28

Family Accession:: 10791787
Method:: Sparcle

Select item 163715.

RdgB/HAM1 family non-canonical purine NTP pyrophosphatase

Saccharomyces cerevisiae HAM1 protects against the mutagenic effects of the base analog 6-N-hydroxylaminopurine, which can be a natural product of monooxygenase activity on adenine. Methanococcus jannaschii MJ0226 and E. coli RdgB are also characterized as pyrophosphatases active against non-standard purines NTPs. E. coli RdgB appears to act by intercepting non-canonical deoxyribonucleotide triphosphates from replication precursor pools.[3]

Gene:: rdgB

GO Terms:

Biological Process:: DNA repair (GO:0006281)

Molecular Function:: dITP diphosphatase activity (GO:0035870)

Molecular Function:: XTP diphosphatase activity (GO:0036222)

Date:: 2024-02-27

Family Accession:: TIGR00042.1
Method:: HMM

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