Protein Family Models

This region encompasses much of the RNA and SrmB binding motifs on polymerase A. [1]. 10361280. Poly(A) polymerase I of Escherichia coli: characterization of. the catalytic domain, an RNA binding site and regions for the. interaction with proteins involved in mRNA degradation.. Raynal LC, Carpousis AJ;. Mol Microbiol. 1999;32:765-775. (from Pfam)

Date:

2024-04-03

The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme. [1]. 10361280. Poly(A) polymerase I of Escherichia coli: characterization of. the catalytic domain, an RNA binding site and regions for the. interaction with proteins involved in mRNA degradation.. Raynal LC, Carpousis AJ;. Mol Microbiol. 1999;32:765-775. (from Pfam)

Date:

2024-04-03

This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily. [1]. 1438224. Identification of the gene for an Escherichia coli poly(A). polymerase.. Cao GJ, Sarkar N;. Proc Natl Acad Sci U S A 1992;89:10380-10384. (from Pfam)

Date:

2024-04-03

This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell [1] [2]. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well [3]. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).

Gene:

pcnB

Date:

2024-05-02