This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1)[1,2,3]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors. [1]. 7651832. Evolution of the SNF2 family of proteins: subfamilies with. distinct sequences and functions.. Eisen JA, Sweder KS, Hanawalt PC;. Nucleic Acids Res. 1995;23:2715-2723.. [2]. 14729263. The SNF2 domain protein family in higher vertebrates displays. dynamic expression patterns in Xenopus laevis embryos.. Linder B, Cabot RA, Schwickert T, Rupp RA;. Gene. 2004;326:59-66.. [3]. 21549307. Maintenance of silent chromatin through replication requires. SWI/SNF-like chromatin remodeler SMARCAD1.. Rowbotham SP, Barki L, Neves-Costa A, Santos F, Dean W, Hawkes. N, Choudhary P, Will WR, Webster J, Oxley D, Green CM,. Varga-Weisz P, Mermoud JE;. Mol Cell. 2011;42:285-296. (from Pfam)
GO Terms:- Molecular Function:
- ATP binding (GO:0005524)
- Molecular Function:
- ATP-dependent chromatin remodeler activity (GO:0140658)
- Date:
- 2024-08-14