Protein Family Models

ZinT plays a critical role in recruiting periplasmic zinc to the bacterial zinc-uptake complex ZnuABC, consisting of families Pfam:PF01297,Pfam:PF00950, Pfam:PF00005, regulated by the transcription-regulator FUR, Pfam:PF01475 [2,3]. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA (TroA), Pfam:PF01297 [4]. Members of this family of prokaryotic domains were first identified as part of the response of bacteria to a challenge with the toxic heavy metal cadmium. They are able to bind to cadmium, and ensure its subsequent elimination [1]. [1]. 12909634. YodA from Escherichia coli is a metal-binding, lipocalin-like. protein.. David G, Blondeau K, Schiltz M, Penel S, Lewit-Bentley A;. J Biol Chem. 2003;278:43728-43735.. [2]. 17931600. Zinc dependence of zinT (yodA) mutants and binding of zinc,. cadmium and mercury by ZinT.. Kershaw CJ, Brown NL, Hobman JL;. Biochem Biophys Res Commun. 2007;364:66-71.. [3]. 21338480. Role of ZnuABC and ZinT in Escherichia coli O157:H7 zinc. acquisition and interaction with epithelial cells.. Gabbianelli R, Scotti R, Ammendola S, Petrarca P, Nicolini L,. Battistoni A;. BMC Microbiol. 2011;11:36.. [4]. 24128931. The Salmonella enterica ZinT structure, zinc affinity and. interaction with the high-affinity uptake protein ZnuA provide. insight into the management of periplasmic zinc.. Ilari A, Alaleona F, Tria G, Petrarca P, Battistoni A,. Zamparelli C, Verzili D, Falconi M, Chiancone E;. Biochim Biophys Acta. 2014;1840:535-544. (from Pfam)

Date:

2024-08-14

ZnuA includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum [1]. ZnuA is part of the bacterial zinc-uptake complex ZnuABC, whose components are the following families, ZinT, Pfam:PF09223, Pfam:PF00950, Pfam:PF00005, all of which are regulated by the transcription-regulator family FUR, Pfam:PF01475. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA (TroA), a high-affinity zinc-uptake protein. In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host [2,3]. [1]. 10404217. Treponema pallidum TroA is a periplasmic zinc-binding protein. with a helical backbone.. Lee YH, Deka RK, Norgard MV, Radolf JD, Hasemann CA;. Nat Struct Biol 1999;6:628-633.. [2]. 21338480. Role of ZnuABC and ZinT in Escherichia coli O157:H7 zinc. acquisition and interaction with epithelial cells.. Gabbianelli R, Scotti R, Ammendola S, Petrarca P, Nicolini L,. Battistoni A;. BMC Microbiol. 2011;11:36.. [3]. 24128931. The Salmonella enterica ZinT structure, zinc affinity and. interaction with the high-affinity uptake protein ZnuA provide. insight into the management of periplasmic zinc.. Ilari A, Alaleona F, Tria G, Petrarca P, Battistoni A,. Zamparelli C, Verzili D, Falconi M, Chiancone E;. Biochim Biophys Acta. 2014;1840:535-544. (from Pfam)

Date:

2024-08-14

zinc ABC transporter substrate-binding protein AdcA functions as the initial receptor in the ATP-driven transport of zinc and/or manganese

Date:

2022-07-19