This is a family of glycosyl-hydrolases of the CAZy GH130 family. Several have been characterised as mannosylglucose phosphorylase [2,3,4]. This enzyme is part of the mannan catalytic pathway and feeds into the glycolysis cycle [2]. Specifically it catalyses the reversible phosphorolysis of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine [4]. This family was noted to belong to the Beta fructosidase superfamily in [1]. [1]. 11093261. beta-fructosidase superfamily: homology with some. alpha-L-arabinases and beta-D-xylosidases.. Naumoff DG;. Proteins. 2001;42:66-76.. [2]. 21539815. New microbial mannan catabolic pathway that involves a novel. mannosylglucose phosphorylase.. Senoura T, Ito S, Taguchi H, Higa M, Hamada S, Matsui H, Ozawa. T, Jin S, Watanabe J, Wasaki J, Ito S;. Biochem Biophys Res Commun. 2011;408:701-706.. [3]. 23093406. Metabolic mechanism of mannan in a ruminal bacterium,. Ruminococcus albus, involving two mannoside phosphorylases and. cellobiose 2-epimerase: discovery of a new carbohydrate. phosphorylase, beta-1,4-mannooligosaccharide phosphorylase.. Kawahara R, Saburi W, Odaka R, Taguchi H, Ito S, Mori H, Matsui. H;. J Biol Chem. 2012;287:42389-42399.. [4]. 23943617. Discovery of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine. phosphorylase involved in the metabolism of N-glycans.. Nihira T, Suzuki E, Kitaoka M, Nishimoto M, Ohtsubo K, Nakai H;. J Biol Chem. 2013;288:27366-27374. (from Pfam)
- Date:
- 2024-07-10