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aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme
PLP-dependent transferase
This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor. [1]. 8831789. Crystal structure of the pyridoxal-5'-phosphate dependent. cystathionine beta-lyase from Escherichia coli at 1.83 A.. Clausen T, Huber R, Laber B, Pohlenz HD, Messerschmidt A;. J Mol Biol 1996;262:202-224.. [2]. 9843488. Crystal structure of Escherichia coli cystathionine. gamma-synthase at 1.5 A resolution.. Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A;. EMBO J 1998;17:6827-6838. (from Pfam)
DegT/DnrJ/EryC1/StrS family aminotransferase
The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA Swiss:P72454, StsC Swiss:P77952 and StsS [1]. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyses the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin [1]. [1]. 9238101. Identification of stsC, the gene encoding the. L-glutamine:scyllo-inosose aminotransferase from. streptomycin-producing Streptomycetes.. Ahlert J, Distler J, Mansouri K, Piepersberg W;. Arch Microbiol 1997;168:102-113. (from Pfam)
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
This HMM describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This HMM is designated subfamily because it may or may not have both activities.
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase is a PLP-dependent enzyme that catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway and/or catalyzes the conversion of O-acetylserine (OAS) into cysteine in the last step of the cysteine biosynthesis pathway
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