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Carbamoyltransferase, Kae1-like Domain, second subdomain
HypF Kae1-like domain
This domain is found in the HypF protein. In the structure it is one of the two subdomains of the Kae1 domain [1]. [1]. 22740694. Structural basis for the reaction mechanism of S-carbamoylation. of HypE by HypF in the maturation of [NiFe]-hydrogenases.. Shomura Y, Higuchi Y;. J Biol Chem. 2012;287:28409-28419. (from Pfam)
HypF finger
The HypF family of proteins are involved in the maturation and regulation of hydrogenase ([1]). In the N-terminus they appear to have two Zinc finger domains, as modelled by this family. [1]. 9492269. Rhodobacter capsulatus HypF is involved in regulation of. hydrogenase synthesis through the HupUV proteins.. Colbeau A, Elsen S, Tomiyama M, Zorin NA, Dimon B, Vignais PM;. Eur J Biochem 1998;251:65-71. (from Pfam)
Sua5/YciO/YrdC/YwlC family protein
This domain has been shown to bind preferentially to dsRNA [1]. The domain is found in SUA5 Swiss:P32579 as well as HypF and YrdC Swiss:P45748. It has also been shown to be required for telomere recombniation in yeast. [1]. 11206077. The structure of the yrdC gene product from Escherichia coli. reveals a new fold and suggests a role in RNA binding.. Teplova M, Tereshko V, Sanishvili R, Joachimiak A, Bushueva T,. Anderson WF, Egli M;. Protein Sci 2000;9:2557-2566.. [2]. 19287007. The universal YrdC/Sua5 family is required for the formation of. threonylcarbamoyladenosine in tRNA.. El Yacoubi B, Lyons B, Cruz Y, Reddy R, Nordin B, Agnelli F,. Williamson JR, Schimmel P, Swairjo MA, de Crecy-Lagard V;. Nucleic Acids Res. 2009;37:2894-2909.. [3]. 19884342. The Sua5 protein is essential for normal translational. regulation in yeast.. Lin CA, Ellis SR, True HL;. Mol Cell Biol. 2010;30:354-363.. [4]. 20309016. Sua5p is required for telomere recombination in Saccharomyces. cerevisiae.. Meng FL, Chen XF, Hu Y, Tang HB, Dang W, Zhou JQ;. Cell Res. 2010;20:495-498. (from Pfam)
acylphosphatase
carbamoyltransferase HypF
carbamoyltransferase HypF is involved in the biosynthesis of the CN ligand of the NiFe(CN)(2)CO centre of [NiFe]-hydrogenase
A previously described regulatory effect of HypF mutatation is attributable to loss of activity of a regulatory hydrogenase. A zinc finger-like region CXXCX(18)CXXCX(24)CXXCX(18)CXXC region further supported the regulatory hypothesis. However, more recent work (PUBMED:11375153) shows the direct effect is on the activity of expressed hydrogenases with nickel/iron centers, rather than on expression.
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