Protein Family Models for Protein (Select 2312126434) - Protein Family Models

Select item 4168921.

Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This enzyme catalyses the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX [1], one of the last steps in haem biosynthesis. The function of this domain is unclear, but comparison to other proteins containing a radical SAM domain (Pfam:PF04055) suggest it may be a substrate binding domain. [1]. 12196143. Terminal steps of haem biosynthesis.. Dailey HA;. Biochem Soc Trans 2002;30:590-595.. [2]. 14633981. Crystal structure of coproporphyrinogen III oxidase reveals. cofactor geometry of Radical SAM enzymes.. Layer G, Moser J, Heinz DW, Jahn D, Schubert WD;. EMBO J. 2003;22:6214-6224. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF018652.5
Method:: HMM

Select item 4152272.

radical SAM protein

Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. [1]. 11222759. Radical SAM, a novel protein superfamily linking unresolved. steps in familiar biosynthetic pathways with radical mechanisms:. functional characterization using new analysis and information. visualization methods.. Sofia HJ, Chen G, Hetzler BG, Reyes-Spindola JF, Miller NE;. Nucleic Acids Res 2001;29:1097-1106.. [2]. 17335281. Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able. to catalyze in vitro sulfatase post-translational modification.. Benjdia A, Leprince J, Guillot A, Vaudry H, Rabot S, Berteau O;. J Am Chem Soc. 2007;129:3462-3463.. [3]. 16766528. A new type of bacterial sulfatase reveals a novel maturation. pathway in prokaryotes.. Berteau O, Guillot A, Benjdia A, Rabot S;. J Biol Chem. 2006;281:22464-22470. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Date:: 2024-09-08

Family Accession:: NF015983.5
Method:: HMM

Select item 3953853.

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Family Accession:

Select item 3921074.

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Family Accession:

Select item 3512925.

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Family Accession:

Select item 3495526.

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Family Accession:

Select item 2086637.

coproporphyrinogen-III oxidase family protein

coproporphyrinogen-III oxidase family protein is a radical SAM protein similar to heme chaperone HemW that transfers heme to an unknown acceptor.

Date:: 2022-08-04

Family Accession:: 11428155
Method:: Sparcle

Select item 196878.

radical SAM family heme chaperone HemW

HemW, a member of the radical SAM family by homology, appears to be a chaperone involved in heme traffic, rather than an actual coproporphyrinogen III oxidase (as it is often annotated) like its homolog HemN.

Gene:: hemW

GO Terms:

Cellular Component:: cytoplasm (GO:0005737)

Biological Process:: porphyrin-containing compound biosynthetic process (GO:0006779)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Molecular Function:: coproporphyrinogen dehydrogenase activity (GO:0051989)

Date:: 2024-05-30

Family Accession:: TIGR00539.1
Method:: HMM

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