Protein Family Models for Protein (Select 2321081033) - Protein Family Models

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Links from Protein

Items: 7

Select item 4240321.

NAD(P)-binding protein

Date:: 2024-08-14

Family Accession:: NF024842.5
Method:: HMM

Select item 4125312.

FAD-dependent oxidoreductase

This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1. [1]. 9153426. Active site plasticity in D-amino acid oxidase: a. crystallographic analysis.. Todone F, Vanoni MA, Mozzarelli A, Bolognesi M, Coda A, Curti B,. Mattevi A;. Biochemistry 1997;36:5853-5860. (from Pfam)

GO Terms:

Molecular Function:: oxidoreductase activity (GO:0016491)

Date:: 2024-08-14

Family Accession:: NF013434.5
Method:: HMM

Select item 4001153.

new record, indexing in progress

Family Accession:

Select item 3887974.

new record, indexing in progress

Family Accession:

Select item 3585805.

new record, indexing in progress

Family Accession:

Select item 3475486.

new record, indexing in progress

Family Accession:

Select item 1469517.

putative aminophosphonate oxidoreductase

This clade of sequences are members of the PF01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.