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MbtH family NRPS accessory protein
This domain is found in the MbtH protein Swiss:O05821 as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologues were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al [1]. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues [2]. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape [3]. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids [3-6]. [1]. 9831524. Identification of a Mycobacterium tuberculosis gene cluster. encoding the biosynthetic enzymes for assembly of the. virulence-conferring siderophore mycobactin.. Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT;. Chem Biol. 1998;5:631-645.. [2]. 12625841. New Knowledge from Old: In silico discovery of novel protein. domains in Streptomyces coelicolor.. Yeats C, Bentley S, Bateman A;. BMC Microbiol 2003;3:3-3.. [3]. 17502378. The 1.8 A crystal structure of PA2412, an MbtH-like protein from. the pyoverdine cluster of Pseudomonas aeruginosa.. Drake EJ, Cao J, Qu J, Shah MB, Straubinger RM, Gulick AM;. J Biol Chem. 2007;282:20425-20434.. [4]. 17464055. Effects of deletions of mbtH-like genes on clorobiocin. biosynthesis in Streptomyces coelicolor.. Wolpert M, Gust B, Kammerer B, Heide L;. Microbiology. 2007;153:1413-1423.. [5]. 17464054. MbtH-like protein-mediated cross-talk between non-ribosomal. peptide antibiotic and siderophore biosynthetic pathways in.. TRUNCATED at 1650 bytes (from Pfam)
MbtH family protein
MbtH family protein may be required for the synthesis of antibiotics, siderophores or glycopeptidolipids
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