Protein Family Models

Members of this family include various bacterial hypothetical proteins, as well as CoA enzyme activases. The exact function of this domain has not, as yet, been defined. (from Pfam)

Date:

2024-08-14

This family includes the BadF Swiss:O07462 and BadG Swiss:O07463 proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase Swiss:P11568. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerise. This family appears to be related to Pfam:PF00370. [1]. 8365476. Identification of the gene encoding the activator of (R)-2-. hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. by gene expression in Escherichia coli.. Bendrat K, Muller U, Klees AG, Buckel W;. FEBS Lett 1993;329:329-331.. [2]. 9746358. Genes coding for the benzoyl-CoA pathway of anaerobic aromatic. metabolism in the bacterium Thauera aromatica.. Breese K, Boll M, Alt-Morbe J, Schagger H, Fuchs G;. Eur J Biochem 1998;256:148-154.. [3]. 9177244. A cluster of bacterial genes for anaerobic benzene ring. biodegradation.. Egland PG, Pelletier DA, Dispensa M, Gibson J, Harwood CS;. Proc Natl Acad Sci U S A 1997;94:6484-6489. (from Pfam)

Date:

2024-08-14

This domain is found in a set of closely related [4Fe-4S]-containing ATPases, including activators of (R)-2-hydroxyglutaryl-CoA dehydratase, (R)-phenyllactate dehydratase, lactoyl-CoA dehydratase, and benzoyl-CoA reductase, as well as the uncharacterized protein YjiL of E. coli. Characterized members of this family provide a key reactive electron that their cognate enzyme requires for activity, and can use for multiple reaction cycles until the electron is lost and needs to be replaced.

Date:

2022-03-20