This domain can be found in uncharacterised proteins in viruses, archaea and bacteria, most notably it is found in YhcG proteins found in E.coli. This entry represents the C-terminal PDDEXK domain belonging to the PD-(D/E)XK superfamily of nucleases involved in DNA recombination and repair [1]. Profile HMM analysis identified a relationship between this C-terminal domain of YhcG and Pfam:PF01939 , a family of NucS endonucleases [2]. YHcG was identified in association with DNA processing enzymes, including the restriction complexes HsdMRS and McrABC, the integrases IntF and IntS, and the recombinase PinE [1]. [1]. 19402753. Global functional atlas of Escherichia coli encompassing. previously uncharacterized proteins.. Hu P, Janga SC, Babu M, Diaz-Mejia JJ, Butland G, Yang W,. Pogoutse O, Guo X, Phanse S, Wong P, Chandran S, Christopoulos. C, Nazarians-Armavil A, Nasseri NK, Musso G, Ali M, Nazemof N,. Eroukova V, Golshani A, Paccanaro A, Greenblatt JF,. Moreno-Hagelsieb G, Emili A;. PLoS Biol. 2009;7:e96.. [2]. 16011798. The PD-(D/E)XK superfamily revisited: identification of new. members among proteins involved in DNA metabolism and functional. predictions for domains of (hitherto) unknown function.. Kosinski J, Feder M, Bujnicki JM;. BMC Bioinformatics. 2005;6:172. (from Pfam)
- Date:
- 2024-04-03