Protein Family Models

This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [2]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [2]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [1] see Swiss:Q01728, Swiss:P48768 and Swiss:P70549 respectively. [1]. 8798769. Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3.. Nicoll DA, Quednau BD, Qui Z, Xia YR, Lusis AJ, Philipson KD;. J Biol Chem 1996;271:24914-24921.. [2]. 1700476. Molecular cloning and functional expression of the cardiac. sarcolemmal Na(+)-Ca2+ exchanger.. Nicoll DA, Longoni S, Philipson KD;. Science 1990;250:562-565. (from Pfam)

Date:

2024-08-14

sodium:calcium antiporter facilitates Na(+)/Ca(2+) exchange

Date:

2018-01-11

This HMM models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat.

Date:

2022-10-11