Protein Family Models

The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices. (from Pfam)

Date:

2024-08-14

The model describes thiamine ABC transporter, permease protein in bacteria. The protein belongs to the larger ABC transport system. It consists of atleast three components: the inner mebrane permease; thiamine binding protein; an ATP-binding subunit. It has been experimentally demonstrated that the mutants in the various steps in the de novo synthesis of the thiamine and the biologically active form, namely thiamine pyrophosphate can be exogenously supplemented with thiamine, thiamine monophosphate (TMP) or thiamine pyrophosphate (TPP).

Gene:

thiP

Date:

2024-06-14

thiamine/thiamine pyrophosphate ABC transporter permease ThiP is part of the ABC transport system ThiBPQ in thiamine import and is responsible for the translocation of the substrate across the membrane

Date:

2017-09-28

Gene:

thiP

Date:

2020-10-26