Protein Family Models

ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer Swiss:O32583. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS [1]. MoaD, Swiss:P30748 a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end. [1]. 10781607. The iscS gene in Escherichia coli is required for the. biosynthesis of 4-thiouridine, thiamin, and NAD.. Lauhon CT, Kambampati R;. J Biol Chem 2000;275:20096-20103. (from Pfam)

Date:

2024-08-14

ThiS ubiquitin-like sulfur carrier protein is involved in thiamin biosynthesis in bacteria

Date:

2023-03-16

This HMM represents ThiS, a small, ubiquitin-like thiamine biosynthesis protein related to MoaD, a molybdenum cofactor biosynthesis protein. Both proteins are involved in sulfur transfer. ThiS has a conserved Gly-Gly C-terminus that is modified, in reactions requiring ThiI, ThiF, IscS, and a sulfur atom from Cys, into the thiocarboxylate that provides the sulfur for thiazole biosynthesis.

Gene:

thiS

Date:

2021-06-07