Protein Family Models

Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts [2]. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif [1]. [1]. 9546395. A novel and ubiquitous system for membrane targeting and. secretion of cofactor-containing proteins.. Weiner JH, Bilous PT, Shaw GM, Lubitz SP, Frost L, Thomas GH,. Cole JA, Turner RJ;. Cell 1998;93:93-101.. [2]. 9367960. Sec-independent protein translocation by the maize Hcf106. protein.. Settles AM, Yonetani A, Baron A, Bush DR, Cline K, Martienssen. R;. Science 1997;278:1467-1470. (from Pfam)

Date:

2024-07-09

twin-arginine translocase TatA/TatE family subunit similar to Sec-independent protein translocase protein TatA, which may form the protein-conducting channel of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes

Date:

2018-07-02

This HMM represents (Twin-Arginine Translocation B) of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins.

Gene:

tatB

Date:

2024-06-04