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PqqD family peptide modification chaperone
This family contains several bacterial coenzyme PQQ synthesis protein D (PqqD) sequences. This protein is required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis [1,2]. [1]. 8002620. Transcriptional analysis of pqqD and study of the regulation of. pyrroloquinoline quinone biosynthesis in Methylobacterium. extorquens AM1.. Ramamoorthi R, Lidstrom ME;. J Bacteriol 1995;177:206-211.. [2]. 12437981. PqqC/D, which converts a biosynthetic intermediate to. pyrroloquinoline quinone.. Toyama H, Fukumoto H, Saeki M, Matsushita K, Adachi O, Lidstrom. ME;. Biochem Biophys Res Commun 2002;299:268-272. (from Pfam)
lasso peptide biosynthesis PqqD family chaperone
Members of this family are homologs of PqqD, a chaperone that binds RiPP peptide precursors for their modification into bioactive natural products. By context, this set is involved in the biosynthesis of threaded-lasso peptides. This model focuses on lasso peptide systems from Actinobacteria. Similar systems, with different subfamilies of PqqD-related peptides, occur in lasso peptide systems in other lineages. A characterized example is LarB1 from the lariatin system of Rhodococcus jostii.
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