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pilin glycosylation ligase domain-containing protein
PglL_A is a pilin glycosylation ligase domain found in Gram negative bacteria [1]. PglL protein O-oligosaccharyltransferases differ from the wider Wzy_C family, Pfam:PF04932, which contains both WaaL O-antigen ligases, in its substrate-specificity. PglL O-oligosaccharyltransferases (O-OTase) transfer oligosaccharide to serine or threonine in a protein. A further indication that the genes identified are PglL rather than WaaL homologues is that they are not located within lipopolysaccharide biosynthetic loci [2]. The specific pilin glycosylation ligases are a subset of the more general bacterial protein o-oligosaccharyltransferases [2]. [1]. 16870136. Pilin glycosylation in Neisseria meningitidis occurs by a. similar pathway to wzy-dependent O-antigen biosynthesis in. Escherichia coli.. Power PM, Seib KL, Jennings MP;. Biochem Biophys Res Commun. 2006;347:904-908.. [2]. 23658772. Identification of bacterial protein o-oligosaccharyltransferases. and their glycoprotein substrates.. Schulz BL, Jen FE, Power PM, Jones CE, Fox KL, Ku SC,. Blanchfield JT, Jennings MP;. PLoS One. 2013;8:e62768. (from Pfam)
Wzy polymerase domain-containing protein
Wzy is a membrane-bound polymerase of 12 TMs, found in Gram-positive bacteria such as Streptococcus pnuemoniae. It forms part of the EPS or exopolysaccharide system. This family is the 6xTMs at the C-terminal end of the molecule. Wzy functions in polymerizing the oligosaccharide repeat subunits to form high-molecular-weight capsular polysaccharides. A contiguous emebrane-bound flippase, Wzx, Pfam:PF01943, transports the repeat units to the external surface of the membrane. These polysaccharides form the capsule and their differing compositions contribute to the multidudinous pneumococcal capsular serotypes, all being structurally and antigenically different [1]. [1]. 18340341. The role of Streptococcus pneumoniae virulence factors in host. respiratory colonization and disease.. Kadioglu A, Weiser JN, Paton JC, Andrew PW;. Nat Rev Microbiol. 2008;6:288-301. (from Pfam)
O-antigen ligase family protein
This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL [1]. [1]. 1624462. Comparison of lipopolysaccharide biosynthesis genes rfaK, rfaL,. rfaY, and rfaZ of Escherichia coli K-12 and Salmonella. typhimurium.. Klena JD, Pradel E, Schnaitman CA;. J Bacteriol. 1992;174:4746-4752. (from Pfam)
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