Protein Family Models

This family now also contains the lysine 2-oxoglutarate reductases. [1]. 11354603. Lysine metabolism in higher plants.. Azevedo RA, Lea PJ;. Amino Acids 2001;20:261-279. (from Pfam)

Date:

2024-08-14

This family now also contains the lysine 2-oxoglutarate reductases. [1]. 11354603. Lysine metabolism in higher plants.. Azevedo RA, Lea PJ;. Amino Acids 2001;20:261-279. (from Pfam)

Date:

2024-08-14

This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. [1]. 8805537. Protein-protein interactions in the pyruvate dehydrogenase. multienzyme complex: dihydrolipoamide dehydrogenase complexed. with the binding domain of dihydrolipoamide acetyltransferase.. Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG;. Structure 1996;4:277-286. (from Pfam)

Date:

2024-08-14

The family of known L-alanine dehydrogenases (EC 1.4.1.1) includes representatives from the Proteobacteria, Firmicutes, Cyanobacteria, and Actinobacteria, all with about 50 % identity or better. An outlier to this group in both sequence and gap pattern is the homolog from Helicobacter pylori, an epsilon division Proteobacteria, which must be considered a putative alanine dehydrogenase. In Mycobacterium smegmatis and M. tuberculosis, the enzyme doubles as a glycine dehydrogenase (1.4.1.10), running in the reverse direction (glyoxylate amination to glycine, with conversion of NADH to NAD+). Related proteins include saccharopine dehydrogenase and the N-terminal half of the NAD(P) transhydrogenase alpha subunit. All of these related proteins bind NAD and/or NADP.

Gene:

ald

Date:

2024-06-21