Protein Family Models

This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model. [1]. 2404764. The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin.. Modelling and structural relationships.. Messerschmidt A, Huber R;. Eur J Biochem 1990;187:341-352.. [2]. 1548698. Refined crystal structure of ascorbate oxidase at 1.9 A. resolution.. Messerschmidt A, Ladenstein R, Huber R, Bolognesi M, Avigliano. L, Petruzzelli R, Rossi A, Finazzi-Agro A;. J Mol Biol 1992;224:179-205.. [3]. 10573417. Natural engineering principles of electron tunnelling in. biological oxidation-reduction.. Page CC, Moser CC, Chen X, Dutton PL;. Nature 1999;402:47-52.. [4]. 7599131. X-ray absorption studies and homology modeling define the. structural features that specify the nature of the copper site. in rusticyanin.. Grossmann JG, Ingledew WJ, Harvey I, Strange RW, Hasnain SS;. Biochemistry 1995;34:8406-8414. (from Pfam)

Date:

2024-08-14

This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model. [1]. 2404764. The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin.. Modelling and structural relationships.. Messerschmidt A, Huber R;. Eur J Biochem 1990;187:341-352.. [2]. 1548698. Refined crystal structure of ascorbate oxidase at 1.9 A. resolution.. Messerschmidt A, Ladenstein R, Huber R, Bolognesi M, Avigliano. L, Petruzzelli R, Rossi A, Finazzi-Agro A;. J Mol Biol 1992;224:179-205.. [3]. 10573417. Natural engineering principles of electron tunnelling in. biological oxidation-reduction.. Page CC, Moser CC, Chen X, Dutton PL;. Nature 1999;402:47-52.. [4]. 7599131. X-ray absorption studies and homology modeling define the. structural features that specify the nature of the copper site. in rusticyanin.. Grossmann JG, Ingledew WJ, Harvey I, Strange RW, Hasnain SS;. Biochemistry 1995;34:8406-8414. (from Pfam)

Date:

2024-08-14

Many of the proteins in this family contain multiple similar copies of this plastocyanin-like domain. [1]. 2404764. The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin.. Modelling and structural relationships.. Messerschmidt A, Huber R;. Eur J Biochem 1990;187:341-352.. [2]. 1548698. Refined crystal structure of ascorbate oxidase at 1.9 A. resolution.. Messerschmidt A, Ladenstein R, Huber R, Bolognesi M, Avigliano. L, Petruzzelli R, Rossi A, Finazzi-Agro A;. J Mol Biol 1992;224:179-205. (from Pfam)

Date:

2024-08-14

This HMM represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export.

Date:

2024-06-21