Protein Family Models for Protein (Select 2623485941) - Protein Family Models

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Links from Protein

Items: 9

Select item 4196861.

DeoR family transcriptional regulator

GO Terms:

Molecular Function:: DNA-binding transcription factor activity (GO:0003700)

Biological Process:: regulation of DNA-templated transcription (GO:0006355)

Date:: 2024-08-14

Family Accession:: NF019826.5
Method:: HMM

Select item 4182082.

HTH domain-containing protein

This family includes helix-turn-helix domains in a wide variety of proteins. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF019884.5
Method:: HMM

Select item 4108373.

DeoR C terminal sensor domain

The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site [1]. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR) [1,2]. It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 16376935. Diversification of catalytic activities and ligand interactions. in the protein fold shared by the sugar isomerases, eIF2B, DeoR. transcription factors, acyl-CoA transferases and. methenyltetrahydrofolate synthetase.. Anantharaman V, Aravind L;. J Mol Biol. 2006;356:823-842.. [2]. 18844374. Quaternary structural transitions in the DeoR-type repressor. UlaR control transcriptional readout from the L-ascorbate. utilization regulon in Escherichia coli.. Garces F, Fernandez FJ, Gomez AM, Perez-Luque R, Campos E,. Prohens R, Aguilar J, Baldoma L, Coll M, Badia J, Vega MC;. Biochemistry. 2008;47:11424-11433. (from Pfam)