Protein Family Models for Protein (Select 2633641246) - Protein Family Models

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Items: 5

Select item 4311911.

Ribosomal RNA large subunit methyltransferase N-terminal domain

Date:: 2024-08-14

Family Accession:: NF044960.2
Method:: HMM

Select item 4152272.

radical SAM protein

Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. [1]. 11222759. Radical SAM, a novel protein superfamily linking unresolved. steps in familiar biosynthetic pathways with radical mechanisms:. functional characterization using new analysis and information. visualization methods.. Sofia HJ, Chen G, Hetzler BG, Reyes-Spindola JF, Miller NE;. Nucleic Acids Res 2001;29:1097-1106.. [2]. 17335281. Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able. to catalyze in vitro sulfatase post-translational modification.. Benjdia A, Leprince J, Guillot A, Vaudry H, Rabot S, Berteau O;. J Am Chem Soc. 2007;129:3462-3463.. [3]. 16766528. A new type of bacterial sulfatase reveals a novel maturation. pathway in prokaryotes.. Berteau O, Guillot A, Benjdia A, Rabot S;. J Biol Chem. 2006;281:22464-22470. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Date:: 2024-09-08

Family Accession:: NF015983.5
Method:: HMM

Select item 4068123.

new record, indexing in progress

Family Accession:

Select item 3921074.

new record, indexing in progress

Family Accession:

Select item 166785.

23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN

Members of this family are RlmN, a 23S rRNA m2A2503 methyltransferase in the radical SAM enzyme family. Closely related is Cfr, a Staphylococcus sciuri plasmid-borne homolog to this family the confers transferrable resistance to chloramphenicol and florfenicol. Cfr methylates adenine(2503) of 23S RNA at position C(8), while RlmN methylates the same residue at a different site, position C(2).