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CDC6, C terminal winged helix domain
The C terminal domain of CDC6 assumes a winged helix fold, with a five alpha-helical bundle (alpha15-alpha19) structure, backed on one side by three beta strands (beta6-beta8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate Cdc6 activity [1]. [1]. 11030343. Structure and function of Cdc6/Cdc18: implications for origin. recognition and checkpoint control.. Liu J, Smith CL, DeRyckere D, DeAngelis K, Martin GS, Berger JM;. Mol Cell. 2000;6:637-648. (from Pfam)
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