The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel. [1]. 15111112. The plug domain of a neisserial TonB-dependent transporter. retains structural integrity in the absence of its transmembrane. beta-barrel.. Oke M, Sarra R, Ghirlando R, Farnaud S, Gorringe AR, Evans RW,. Buchanan SK;. FEBS Lett 2004;564:294-300. (from Pfam)
- Date:
- 2024-04-03