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HWE histidine kinase domain-containing protein
Two-component systems, consisting of a histidine kinase and a cognate response regulator protein, represent the best-known apparatus for transducing external cues into a physiological response in bacteria. The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as Pfam:PF00512 [1] and Pfam:PF07568 [2]. The family was defined by [1] the presence of a highly conserved H residue in the kinase domain and a WxE motif in a C-terminal ATPase domain that is related to Pfam:PF02518. It has been demonstrated to show structural and functional correlation with Pfam:PF07568 [2]. These proteins are found in a variety of alpha- and gamma- proteobacteria, with significant enrichment in the rhizobia. [1]. 14702314. The HWE Histidine Kinases, a New Family of Bacterial. Two-Component Sensor Kinases with Potentially Diverse Roles in. Environmental Signaling.. Karniol B, Vierstra RD;. J Bacteriol 2004;186:445-453.. [2]. 28193573. Structure and function of HWE/HisKA2-family sensor histidine. kinases.. Herrou J, Crosson S, Fiebig A;. Curr Opin Microbiol. 2017;36:47-54. (from Pfam)
histidine kinase dimerization/phosphoacceptor domain -containing protein
This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases [1]. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536 [2]. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea. [1]. 10500846. The histidine protein kinase superfamily.. Grebe TW, Stock JB;. Adv Microb Physiol 1999;41:139-227.. [2]. 28193573. Structure and function of HWE/HisKA2-family sensor histidine. kinases.. Herrou J, Crosson S, Fiebig A;. Curr Opin Microbiol. 2017;36:47-54. (from Pfam)
CHASE domain-containing protein
This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases [1,2]. This is a ligand-binding domain that binds cytokinin (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 11590000. The CHASE domain: a predicted ligand-binding module in plant. cytokinin receptors and other eukaryotic and bacterial. receptors.. Anantharaman V, Aravind L;. Trends Biochem Sci 2001;26:579-582.. [2]. 11590001. CHASE: an extracellular sensing domain common to transmembrane. receptors from prokaryotes, lower eukaryotes and plants.. Mougel C, Zhulin IB;. Trends Biochem Sci 2001;26:582-584. (from Pfam)
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