Protein Family Models

Members of this family belong to the PD-(D/E)XK nuclease superfamily [1]. 15972856. Identification of novel restriction endonuclease-like fold. families among hypothetical proteins.. Kinch LN, Ginalski K, Rychlewski L, Grishin NV;. Nucleic Acids Res. 2005;33:3598-3605. (from Pfam)

Date:

2024-08-14

This domain has no known function. The domain contains three conserved cysteines at its C terminus. [1]. 15972856. Identification of novel restriction endonuclease-like fold. families among hypothetical proteins.. Kinch LN, Ginalski K, Rychlewski L, Grishin NV;. Nucleic Acids Res. 2005;33:3598-3605. (from Pfam)

Date:

2024-08-14

Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR [2]. [1]. 16292354. A guild of 45 CRISPR-associated (Cas) protein families and. multiple CRISPR/Cas subtypes exist in prokaryotic genomes.. Haft DH, Selengut J, Mongodin EF, Nelson KE;. PLoS Comput Biol. 2005;1:e60.. [2]. 16079334. Clustered regularly interspaced short palindrome repeats. (CRISPRs) have spacers of extrachromosomal origin.. Bolotin A, Quinquis B, Sorokin A, Ehrlich SD;. Microbiology. 2005;151:2551-2561. (from Pfam)

Date:

2024-08-14

This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.

Gene:

cas1

Date:

2021-04-27