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NACHT-associated inactive Restriction Endonuclease 1
winged helix-turn-helix domain-containing protein
This domain is found at the N-terminus of the Mrr restriction endonuclease catalytic domain, Pfam:PF04471 [1,2]. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition [2]. [1]. 11313145. Identification of a PD-(D/E)XK-like domain with a novel. configuration of the endonuclease active site in the. methyl-directed restriction enzyme Mrr and its homologs.. Bujnicki JM, Rychlewski L;. Gene 2001;267:183-191.. [2]. 18951880. Mutational analysis and a structural model of methyl-directed. restriction enzyme Mrr.. Orlowski J, Mebrhatu MT, Michiels CW, Bujnicki JM, Aertsen A;. Biochem Biophys Res Commun. 2008;377:862-866. (from Pfam)
Restriction endonuclease
Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2] [1]. 1650347. Characterization and expression of the Escherichia coli Mrr. restriction system.. Waite-Rees PA, Keating CJ, Moran LS, Slatko BE, Hornstra LJ,. Benner JS;. J Bacteriol 1991;173:5207-5219.. [2]. 11313145. Identification of a PD-(D/E)XK-like domain with a novel. configuration of the endonuclease active site in the. methyl-directed restriction enzyme Mrr and its homologs.. Bujnicki JM, Rychlewski L;. Gene 2001;267:183-191. (from Pfam)
restriction endonuclease
Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2]. [1]. 1650347. Characterization and expression of the Escherichia coli Mrr. restriction system.. Waite-Rees PA, Keating CJ, Moran LS, Slatko BE, Hornstra LJ,. Benner JS;. J Bacteriol 1991;173:5207-5219.. [2]. 11313145. Identification of a PD-(D/E)XK-like domain with a novel. configuration of the endonuclease active site in the. methyl-directed restriction enzyme Mrr and its homologs.. Bujnicki JM, Rychlewski L;. Gene 2001;267:183-191. (from Pfam)
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