Protein Family Models for Protein (Select 2714594922) - Protein Family Models

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Items: 6

Select item 4128851.

6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

This entry represents the N-terminal ribonuclease-like domain associated with 6-O-methylguanine DNA methyltransferase activity. The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (also known as O-6-methylguanine-DNA-alkyltransferase) [1]. 8156986. Crystal structure of a suicidal DNA repair protein: the Ada. O6-methylguanine-DNA methyltransferase from E. coli.. Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PC;. EMBO J 1994;13:1495-1501. (from Pfam)

GO Terms:

Molecular Function:: methylated-DNA-[protein]-cysteine S-methyltransferase activity (GO:0003908)

Biological Process:: DNA repair (GO:0006281)

Date:: 2024-08-14

Family Accession:: NF014870.5
Method:: HMM

Select item 4127432.

MGMT family protein

This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases [1]. [1]. 8156986. Crystal structure of a suicidal DNA repair protein: the Ada. O6-methylguanine-DNA methyltransferase from E. coli.. Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PC;. EMBO J 1994;13:1495-1501. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Biological Process:: DNA repair (GO:0006281)

Date:: 2024-08-14

Family Accession:: NF013222.5
Method:: HMM

Select item 3900473.

new record, indexing in progress

Family Accession:

Select item 3898204.

new record, indexing in progress

Family Accession:

Select item 2963685.

methylated-DNA--[protein]-cysteine S-methyltransferase

Gene:: adaB

Date:: 2021-01-01

Family Accession:: NBR013714
Method:: BlastRule

Select item 220676.

methylated-DNA--[protein]-cysteine S-methyltransferase

All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

GO Terms: