Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins [1]. Also in the family is cephalosporin acylase Swiss:P07662 and Swiss:P29958 aculeacin A acylase which are involved in the synthesis of related peptide antibiotics. [1]. 9292993. Molecular cloning and analysis of the gene encoding the. thermostable penicillin G acylase from Alcaligenes faecalis.. Verhaert RM, Riemens AM, van der Laan JM, van Duin J, Quax WJ;. Appl Environ Microbiol 1997;63:3412-3418.. [2]. 7816145. Penicillin acylase has a single-amino-acid catalytic centre.. Duggleby HJ, Tolley SP, Hill CP, Dodson EJ, Dodson G, Moody PC;. Nature 1995;373:264-268. (from Pfam)
GO Terms:- Molecular Function:
- hydrolase activity (GO:0016787)
- Biological Process:
- antibiotic biosynthetic process (GO:0017000)
- Date:
- 2024-04-03