Protein Family Models for Protein (Select 2734168052) - Protein Family Models

Select item 4173281.

This HMM hits multiple proteins of peptidoglycan (murein) biosynthesis, such as MurC, MurD, MurE, and MurF of Escherichia coli.

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2024-08-14

Family Accession:: NF019850.5
Method:: HMM

Select item 4136942.

glutamate ligase domain-containing protein

This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate. [1]. 9218784. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate. ligase from Escherichia coli.. Bertrand JA, Auger G, Fanchon E, Martin L, Blanot D, van. Heijenoort J, Dideberg O;. EMBO J 1997;16:3416-3425. (from Pfam)

GO Terms:

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2024-08-14

Family Accession:: NF014874.5
Method:: HMM

Select item 4120613.

Mur ligase domain-containing protein

This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate. [1]. 9218784. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate. ligase from Escherichia coli.. Bertrand JA, Auger G, Fanchon E, Martin L, Blanot D, van. Heijenoort J, Dideberg O;. EMBO J 1997;16:3416-3425. (from Pfam)

GO Terms:

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2024-08-14

Family Accession:: NF013396.5
Method:: HMM

Select item 3947244.

new record, indexing in progress

Family Accession:

Select item 3904305.

new record, indexing in progress

Family Accession:

Select item 3889316.

new record, indexing in progress

Family Accession:

Select item 257527.

UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase

Alternate name: murein tripeptide ligase

Gene:: mpl

GO Terms:

Biological Process:: peptidoglycan biosynthetic process (GO:0009252)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Biological Process:: cell wall organization (GO:0071555)

Date:: 2024-05-30

Family Accession:: TIGR01081.1
Method:: HMM

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