Protein Family Models for Protein (Select 2738576189) - Protein Family Models

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Items: 5

Select item 4119151.

aconitase family protein

Members of this family include aconitase (aconitate hydratase), 3-isopropylmalate dehydratase, and homoaconitase.

Date:: 2024-08-14

Family Accession:: NF012550.5
Method:: HMM

Select item 3888312.

new record, indexing in progress

Family Accession:

Select item 359503.

3-isopropylmalate dehydratase large subunit

Date:: 2020-10-26

Family Accession:: NF004016.0
Method:: HMM

Select item 296714.

3-isopropylmalate dehydratase large subunit

Date:: 2020-10-26

Family Accession:: NF009116.0
Method:: HMM

Select item 161215.

3-isopropylmalate dehydratase large subunit

Members of this family are 3-isopropylmalate dehydratase, large subunit, or the large subunit domain of single-chain forms. Homoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures. All are dehydratases (EC 4.2.1.-) and bind a Fe-4S iron-sulfur cluster. 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble the leuC and leuD pair in length and sequence but even more closely resemble the respective domains of homoaconitase, and their identity is uncertain. These homologs are now described by a separate model of subfamily (rather than equivalog) homology type, and the priors and cutoffs for this model have been changed to focus this equivalog family more narrowly.