Protein Family Models

This family includes the TusA sulfurtransferases [1]. [1]. 16387657. Mechanistic insights into sulfur relay by multiple sulfur. mediators involved in thiouridine biosynthesis at tRNA wobble. positions.. Ikeuchi Y, Shigi N, Kato J, Nishimura A, Suzuki T;. Mol Cell. 2006;21:97-108. (from Pfam)

Date:

2024-08-14

Members of this protein family are about 200 amino acids in size, and have an N-terminal region, modeled by PF01206, similar to the much shorter TusA (also called SirA) and its homologs YedF and YeeD The C-terminal domain includes a typical redox-active disulfide motif, CGXC. This protein family is found only among those genomes that also carry the selenium donor protein SelD, and its connection to selenium metabolism is indicated by the method of partial phylogenetic profiling [1] vs. SelD. Its gene typically is found next to selD. Members of this family are found even when selenocysteine and selenouridine biosynthesis pathways are, except for SelD, completely absent, as in Enterococcus faecalis. Its role in selenium metabolism is unclear, but may include either detoxification or a role in labile selenoprotein biosynthesis. This family does not include the E. coli protein designated YedF, but instead consists of related proteins

Gene:

yedF

Date:

2022-03-28