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phosphotransferase
This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation [2]. This family also includes homoserine kinase. This family is related to fructosamine kinase Pfam:PF03881. [1]. 2163618. Cloning of aminoglycoside phosphotransferase (APH) gene from. antibiotic- producing strain of Bacillus circulans into a. high-expression vector, pKK223-3. Purification, properties and. location of the enzyme [published erratum appears in Biochem J. 1991 Feb 1. Sarwar M, Akhtar M;. Biochem J 1990;268:671-677.. [2]. 2167474. PCR cloning of a streptomycin phosphotransferase (aphE) gene. from Streptomyces griseus ATCC 12475.. Trower MK, Clark KG;. Nucleic Acids Res 1990;18:4615-4615. (from Pfam)
aminoglycoside 3'-phosphotransferase
aminoglycoside 3'-phosphotransferase phosphorylates and inactives antibiotic substrates such as kanamycin, streptomycin, neomycin, and gentamicin, among others
APH(3') family aminoglycoside O-phosphotransferase
APH(3')-I family aminoglycoside O-phosphotransferase
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