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NAD(P)H-hydrate dehydratase
This family is related to Pfam:PF02110 and Pfam:PF00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C). (from Pfam)
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
ATP-dependent (S)-NAD(P)H-hydrate dehydratase catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP; together with NAD(P)HX epimerase, repairs both epimers of NAD(P)HX, a damaged form of NAD(P)H
E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. With search program hmmsw, the present model hits hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis, with scores between 10 and 30. The noise cutoff for this family is set higher, at 40 bits.
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