Protein Family Models

This family contains the C-terminal domain of ribosomal protein TL5. The N-terminal domain, which binds to 5S rRNA, is contained in family Ribosomal_L25p, Pfam:PF01386. Full length (N- and C-terminal domain) homologues of TL5 are also known as CTC proteins. TL5 or CTC are not found in Eukarya or Archaea. In some Bacteria, including E. coli, this ribosomal subunit occurs as a single domain protein (named Ribosomal subunit L25), where the only domain is homologous to TL5 N-terminal domain (hence included in family Pfam:PF01386). The function of the C-terminal domain of TLC is at present unknown. [1]. 11418764. Structure of ribosomal protein TL5 complexed with RNA provides. new insights into the CTC family of stress proteins.. Fedorov R, Meshcheryakov V, Gongadze G, Fomenkova N, Nevskaya N,. Selmer M, Laurberg M, Kristensen O, Al-Karadaghi S, Liljas A,. Garber M, Nikonov S;. Acta Crystallogr D Biol Crystallogr. 2001;57:968-976. (from Pfam)

Date:

2024-08-14

Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. This family includes Ctc from B. subtilis Swiss:P14194, which is induced by stress. [1]. 9799245. The NMR structure of Escherichia coli ribosomal protein L25. shows homology to general stress proteins and glutaminyl-tRNA. synthetases.. Stoldt M, Wohnert J, Gorlach M, Brown LR;. EMBO J 1998;17:6377-6384.. [2]. 10562563. The NMR structure of the 5S rRNA E-domain-protein L25 complex. shows preformed and induced recognition.. Stoldt M, Wohnert J, Ohlenschlager O, Gorlach M, Brown LR;. EMBO J 1999;18:6508-6521. (from Pfam)

Date:

2024-08-14

50S ribosomal protein L25 is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance

Date:

2018-03-19

Date:

2020-10-26

This HMM models a family of proteins with full-length homology to the general stress protein Ctc of Bacillus subtilis, a mesophile, and ribosomal protein TL5 of Thermus thermophilus, a thermophile. Ribosomal protein L25 of Escherichia coli and H. influenzae appear to be orthologous but consist only of the N-terminal half of Ctc and TL5. Both short (L25-like) and full-length (CTC-like) members of this family bind the E-loop of bacterial 5S rRNA. This protein appears to be restricted to bacteria and organelles, and consists of at most one copy per prokaryotic genome.Ctc of Bacillus subtilis has now been localized to ribosomes and can be viewed as the long form, or Ctc form, of L25. The C-terminal domain of sll1824, an apparent L25 of Synechocystis PCC6803, matches the N-terminal domain of this family. Examples of L25 and Ctc are not separated by a UPGMA tree built on the region of shared homology.

Date:

2024-05-28