Protein Family Models

These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, Pfam:PF01758. (from Pfam)

Date:

2024-08-14

This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+ [2]. Also in the family is ARC3 from S. cerevisiae Swiss:Q06598 this is a putative transmembrane protein involved in resistance to arsenic compounds [1]. [1]. 9234670. Isolation of three contiguous genes, ACR1, ACR2 and ACR3,. involved in resistance to arsenic compounds in the yeast. Saccharomyces cerevisiae.. Bobrowicz P, Wysocki R, Owsianik G, Goffeau A, Ulaszewski S;. Yeast 1997;13:819-828.. [2]. 1961729. Functional expression cloning and characterization of the. hepatocyte Na+/bile acid cotransport system.. Hagenbuch B, Stieger B, Foguet M, Lubbert H, Meier PJ;. Proc Natl Acad Sci U S A 1991;88:10629-10633. (from Pfam)

Date:

2024-08-14

arsenic resistance protein is a plasma membrane transporter that confers resistance to toxic metalloids (e.g.arsenite) by mediating extrusion of those compounds out of cells

Date:

2024-08-27

The Arsenical Resistance-3 (ACR3) Family (TC 2.A.59) The first protein of the ACR3 family functionally characterized was the ACR3 protein of Saccharomyces cerevisiae. It is present in the yeast plasma membrane and pumps arsenite out of the cell in response to the pmf. Similar proteins are found in bacteria, often as part of a four gene operon with an regulatory protein ArsR, a protein of unknown function ArsH, and an arsenate reductase that converts arsenate to arsenite to facilitate transport.

Gene:

arsB

Date:

2024-06-10