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toxin-activating lysine-acyltransferase
Members of this family are enzymes EC:2.3.1.-. involved in fatty acylation of the protoxins (HlyA) at lysine residues, thereby converting them to the active toxin. Acyl-acyl carrier protein (ACP) is the essential acyl donor. This family show a number of conserved residues that are possible candidates for participation in acyl transfer. Site-directed mutagenesis of the single conserved histidine residue in Swiss:P06736 resulted in complete inactivation of the enzyme [1]. [1]. 10079090. HlyC, the internal protein acyltransferase that activates. hemolysin toxin: role of conserved histidine, serine, and. cysteine residues in enzymatic activity as probed by chemical. modification and site-directed mutagenesis.. Trent MS, Worsham LM, Ernst-Fonberg ML;. Biochemistry 1999;38:3433-3439. (from Pfam)
alpha-hemolysin-activating lysine-acyltransferase HlyC
protein-lysine palmitoyltransferase
protein-lysine palmitoyltransferase catalyzes palmitoylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin
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