Protein Family Models

This family features the C-terminal region of a number of proteins that bear similarity to the QacR protein (Swiss:P23217), a transcriptional regulator of the TetR family. QacR is able to bind various environmental agents, which include a number of cationic lipophilic compounds, and thus regulate the transcription of QacA (Swiss:P23215), a multidrug efflux pump [1]. The C-terminal region contains the multifaceted, expansive drug-binding pocket, which is composed of several separate, but linked, binding sites [2]. [1]. 9660841. QacR is a repressor protein that regulates expression of the. Staphylococcus aureus multidrug efflux pump QacA.. Grkovic S, Brown MH, Roberts NJ, Paulsen IT, Skurray RA;. J Biol Chem 1998;273:18665-18673.. [2]. 11739955. Structural mechanisms of QacR induction and multidrug. recognition.. Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA,. Brennan RG;. Science 2001;294:2158-2163. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance; similar to Staphylococcus aureus HTH-type transcriptional regulator QacR

Date:

2020-07-16

QacR, a TetR family transcriptional regulator, binds multiple antimicrobial compounds, and controls expression of quaternary ammonium compound (qac) efflux transporter QacA.

Gene:

qacR

Date:

2018-12-28