Protein Family Models

The HMG-CoA reductases catalyse the conversion of HMG-CoA to mevalonate, which is the rate-limiting step in the synthesis of isoprenoids like cholesterol. Probably because of the critical role of this enzyme in cholesterol homeostasis, mammalian HMG-CoA reductase is heavily regulated at the transcriptional, translational, and post-translational levels [2]. [1]. 7792601. Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at. 3.0 angstrom resolution.. Lawrence CM, Rodwell VW, Stauffacher CV;. Science 1995;268:1758-1762.. [2]. 15535874. The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.. Friesen JA, Rodwell VW;. Genome Biol 2004;5:248. (from Pfam)

Date:

2024-08-14

Most known examples of hydroxymethylglutaryl-CoA reductase are NADP-dependent (EC 1.1.1.34) from eukaryotes and archaea, involved in the biosynthesis of mevalonate from 3-hydroxy-3-methylglutaryl-CoA. This model, in contrast, is built from the two examples in completed genomes of sequences closely related to the degradative, NAD-dependent hydroxymethylglutaryl-CoA reductase of Pseudomonas mevalonii, a bacterium that can use mevalonate as its sole carbon source.

Date:

2024-06-11