Copper homeostasis protein CutC was originally thought to be involved in copper tolerance in Escherichia coli, as mutation in the corresponding gene lead to an increased copper sensitivity [1]. However, this phenotype has been later reported to depend on the levels of he mRNA-interfering complementary RNA regulator MicL, which is transcribed from a promoter located within the coding sequence of the cutC gene in enterobacteria [2]. In the plant pathogen Xylella fastidiosa, this protein has been reported as specific for copper efflux [3]. The structure of this protein in the bacteria Shigella flexneri showed a monomer structure that adopts a common TIM beta/alpha barrel with eight beta strands surrounded by eight alpha-helices [4]. The human homologue of this protein, whose structure showed a potential copper-binding site, has an important role in intracellular copper homeostasis [5,6]. [1]. 7635807. Identification of cutC and cutF (nlpE) genes involved in copper. tolerance in Escherichia coli.. Gupta SD, Lee BT, Camakaris J, Wu HC;. J Bacteriol 1995;177:4207-4215.. [2]. 25030700. MicL, a new sigmaE-dependent sRNA, combats envelope stress by. repressing synthesis of Lpp, the major outer membrane. lipoprotein.. Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G;. Genes Dev. 2014;28:1620-1634.. [3]. 34616378. Overexpression of mqsR in Xylella fastidiosa Leads to a Priming. Effect of Cells to Copper Stress Tolerance.. Carvalho IGB, Merfa MV, Teixeira-Silva NS, Martins PMM, Takita. MA, de Souza AA;. Front Microbiol. 2021;12:712564.. [4]. 15624211. Crystal structure of the copper homeostasis protein (CutCm) from. Shi. TRUNCATED at 1650 bytes (from Pfam)
GO Terms:- Molecular Function:
- copper ion binding (GO:0005507)
- Biological Process:
- copper ion homeostasis (GO:0055070)
- Date:
- 2024-08-14