Protein Family Models for Protein (Select 489242490) - Protein Family Models

Select item 4317001.

RecR, helix-hairpin-helix

Date:: 2024-08-14

Family Accession:: NF045310.2
Method:: HMM

Select item 4302912.

RecR, C-terminal

Date:: 2024-08-14

Family Accession:: NF044419.2
Method:: HMM

Select item 4221933.

toprim domain-containing protein

The toprim domain is found in a wide variety of enzymes involved in nucleic acid manipulation [1]. [1]. 9722641. Toprim--a conserved catalytic domain in type IA and II. topoisomerases, DnaG-type primases, OLD family nucleases and. RecR proteins.. Aravind L, Leipe DD, Koonin EV;. Nucleic Acids Res 1998;26:4205-4213. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF025044.5
Method:: HMM

Select item 4124714.

RecR, Cys4-zinc finger motif

GO Terms:

Molecular Function:: metal ion binding (GO:0046872)

Date:: 2024-08-14

Family Accession:: NF014217.5
Method:: HMM

Select item 4124485.

toprim domain-containing protein

This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1]. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity [1]. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division [2]. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases [4]. Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks. [1]. 9722641. Toprim--a conserved catalytic domain in type IA and II. topoisomerases, DnaG-type primases, OLD family nucleases and. RecR proteins.. Aravind L, Leipe DD, Koonin EV;. Nucleic Acids Res 1998;26:4205-4213.. [2]. 9224947. Cloning and analysis of the dnaG gene encoding Pseudomonas. putida DNA primase.. Szafranski P, Smith CL, Cantor CR;. Biochim Biophys Acta 1997;1352:243-248.. [3]. 8294018. The Haemophilus influenzae dnaG sequence and conserved bacterial. primase motifs.. Versalovic J, Lupski JR;. Gene 1993;136:281-286.. [4]. 9121560. An atypical topoisomerase II from Archaea with implications for. meiotic recombination.. Bergerat A, de Massy B, Gadelle D, Varoutas PC, Nicolas A,. Forterre P;. Nature 1997;386:414-417. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF013878.5
Method:: HMM

Select item 4083116.